Special Issue Information

Mitochondria are vital organelles that regulate cellular homeostasis, energy metabolism, signal transduction, and epigenetic modifications. Their dysfunction is closely linked to the onset and progression of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, pulmonary conditions, and liver disorders. Given their fundamental role in cellular function, mitochondria have become a key target for therapeutic interventions.

Recent advances in nanotechnology have paved the way for innovative approaches to mitigate mitochondrial dysfunction. Researchers are actively developing mitochondria-targeted nanomaterials to prevent oxidative damage, alleviate oxidative stress, reduce mitochondrial DNA (mtDNA) damage, and enhance mitophagy. These advancements hold great promise in slowing disease progression and improving therapeutic outcomes.

This Special Issue aims to highlight recent developments in mitochondria-targeted nanomaterials, encompassing their synthesis, characterization, and biomedical applications. We invite original research and review articles on topics including but not limited to:

• Design and synthesis of mitochondria-targeted nanomaterials 
• Applications in cancer, neurodegenerative, cardiovascular, pulmonary, liver, and metabolic diseases 
• Strategies for enhancing mitochondrial drug delivery 
• Nanomaterials for oxidative stress mitigation and mitochondrial protection 
• Therapeutic potential of nanotechnology in ischemia-reperfusion injuries

We welcome contributions that advance the understanding and clinical translation of mitochondria-targeted nanomaterials, fostering innovative solutions for mitochondria-related diseases.

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