Special Issue Information

Mitochondria are essential organelles responsible for maintaining cellular homeostasis and regulating key biological processes such as signal transduction, epigenetic regulation, apoptosis, autophagy, and cell proliferation. Mitochondrial dysfunction is closely linked to the onset and progression of various diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, and metabolic and inflammatory conditions.

In recent years, growing attention has been directed toward developing nanomaterials that can target and restore mitochondrial function. These include strategies to prevent oxidative damage, reduce mitochondrial DNA (mtDNA) injury, enhance autophagy, and improve drug delivery to mitochondria.

This Special Issue aims to showcase the latest advances in the design, synthesis, and biomedical application of mitochondria-targeted nanomaterials for the treatment of mitochondria-related diseases. We welcome original research and review articles covering (but not limited to) the following topics:

• Design and synthesis of mitochondria-targeting nanomaterials
• Nanomaterial-based therapies for mitochondrial dysfunction in cancer
• Neuroprotective nanomaterials for neurodegenerative diseases
• Mitochondria-related nanotherapies for pulmonary and liver diseases
• Applications in cardiovascular diseases, diabetes, and ischemia-reperfusion injury
• Advances in mitochondria-related nanomaterials and biomedical applications

We invite researchers in nanomedicine, mitochondrial biology, and translational medicine to contribute their latest findings to this timely and impactful collection.

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