On October 28, 2026, Ferroptosis and Oxidative Stress (FOS) held the second session of its FOS Global Forum Series, bringing together researchers for a discussion on the role of ergothioneine in neuroprotection.

The webinar featured a lecture by Professor Barry Halliwell of the National University of Singapore, titled "Ergothioneine – A Novel Neuroprotective Agent: Antioxidant and Much More," with Professor D. Allan Butterfield from the University of Kentucky serving as moderator.

Professor Halliwell discussed the biological properties of ergothioneine and its potential role in neuroprotection, covering evidence from human observational studies, experimental models, and a pilot clinical trial.

His lecture addressed its effects on inflammation and mitochondrial function, as well as its antioxidant activity and potential to inhibit ferroptosis. He also discussed questions that remain about its mechanisms of action and the need for further clinical studies.

The discussion also brought together four panelists:
Professor Christopher Chen of the National University of Singapore,
Professor Robert B. Beelman of the Penn State University,
Dr. Irwin Kee-Mun Cheah of the National University of Singapore, and
Professor Richard Siow of King's College London and the University of Oxford.

The discussion covered different aspects of ergothioneine research, including its role in redox biology, neuroprotection, and nutrition. The panelists also discussed the evidence supporting its potential health benefits and the questions that remain to be addressed through further research.

The FOS Editorial Office extends its thanks to Professor Halliwell, Professor Butterfield, all four panelists, and everyone who joined the webinar. The FOS Global Forum Series will continue with future sessions exploring topics in ferroptosis, oxidative stress, and related areas of research.