Manuscript Title: Multi-level regulation of CtIP, BRCA1, and RAD51 expression: From transcription to post-translational modification
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Manuscript Title: Multi-level regulation of CtIP, BRCA1, and RAD51 expression: From transcription to post-translational modification

Yuheon Chung
1
,
Minyoung Kim
1,2
,
Seula Jeong
1
,
Enkhzul Amarsanaa
1,3
,
Yoonsung Lee
4
,
Kyungjae Myung
1,3,*
*Correspondence to: Kyungjae Myung, Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. E-mail: kmyung@ibs.re.krkmyung@ibs.re.kr
Ageing Cancer Res Treat. 2026;3:202613. 10.70401/acrt.2026.0029
Received: March 30, 2026Accepted: June 26, 2026Published: July 01, 2026
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This manuscript is made available in its unedited form to allow early access to the reported findings. Further editing will be completed before final publication. As such, the content may include errors, and standard legal disclaimers are applicable.

Abstract

Homologous recombination (HR) is a high-fidelity DNA double-strand break repair pathway that plays a central role in preserving genome stability and suppressing tumorigenesis. Core HR proteins, including CtIP, BRCA1, and RAD51, function in a tightly coordinated manner to mediate DNA end resection, pathway choice, and homology-directed strand exchange. Increasing evidence indicates that the abundance, activity, and chromatin engagement of these HR regulators are not constitutive but are dynamically controlled across multiple regulatory layers, including transcriptional programs, post-transcriptional RNA regulation, and post-translational proteostasis mechanisms. These regulatory systems integrate cell-cycle, stress signaling, and metabolic context to regulate HR capacity. In this review, we present an integrated framework describing how CtIP, BRCA1, and RAD51 are regulated across transcriptional, post-transcriptional, and post-translational levels, with emphasis on mechanisms that jointly control multiple HR proteins as well as gene-specific regulatory modules.

Keywords

Homologous recombination, CtIP, BRCA1, RAD51, post-translational regulation

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Chung Y, Kim M, Jeong S, Amarsanaa E, Lee Y, Myung K. Manuscript Title: Multi-level regulation of CtIP, BRCA1, and RAD51 expression: From transcription to post-translational modification. Ageing Cancer Res Treat. 2026;3:202613. https://doi.org/10.70401/acrt.2026.0029

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