Catalytic asymmetric synthesis of chiral carboxylic acids and heterocycles with CO2
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Catalytic asymmetric synthesis of chiral carboxylic acids and heterocycles with CO2

Deyong Yang
1
,
Han Zhou
1
,
Lele Wang
1
,
Huimin Wang
1
,
Mengmeng Jiang
1
,
Yixiao Zhang
1
,
Dingying Chen
1
,
Xianglin Pan
2
,
Jian Zhou
1
,
Feng Zhou
1,*
*Correspondence to: Feng Zhou, State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China. E-mail: fzhou@chem.ecnu.edu.cn
Chiral Chem. 2027;3:202633. 10.70401/cc.2026.0038
Received: July 18, 2026Accepted: September 07, 2026Published: September 07, 2026
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This manuscript is made available in its unedited form to allow early access to the reported findings. Further editing will be completed before final publication. As such, the content may include errors, and standard legal disclaimers are applicable.

Abstract

The development of asymmetric catalytic methods using CO2 as a C1 synthon is an important strategy for constructing chiral carboxylic acids and heterocyclic compounds. In recent years, through the design of innovative catalytic systems, efficient and highly selective syntheses of chiral carboxylic acids, spanning central to axial chirality, have been achieved from diverse substrates, including alkenes, alkynes, and organic electrophiles. Concurrently, significant progress has also been made in the synthesis of chiral heterocycles, particularly 2-oxazolidinones and cyclic carbonates. This review systematically summarizes key advances in this field from 2021 to mid-2026. Organized by target product structure, the discussion first addresses chiral carboxylic acids, categorized by substrate type (carbon-carbon unsaturated bonds and organic electrophiles). Key strategies, including carbo-carboxylation, boracarboxylation, hydrocarboxylation, dicarboxylation, and electroreductive carboxylation, are elaborated in detail, along with their stereoselectivity control mechanisms. The discussion then covers chiral heterocycles, summarizing the catalytic asymmetric construction of chiral 2-oxazolidinones and chiral cyclic carbonates. Finally, the major challenges and future directions in this field are discussed.

Keywords

Carbon dioxide fixation, C1 synthons, asymmetric catalysis, enantioselective carboxylation, chiral carboxylic acids, chiral heterocycles

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© The Author(s) 2027. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Yang D, Zhou H, Wang L, Wang H, Jiang M, Zhang Y, et al. Catalytic asymmetric synthesis of chiral carboxylic acids and heterocycles with CO2. Chiral Chem. 2027;3:202633. https://doi.org/10.70401/cc.2026.0038

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