Integration of inorganic fillers with polymer matrices opens up exciting possibilities for creating high-performance functional materials. Metal/metal oxides/silsesquioxanes as nanofillers are gaining attention for enhancing polymer matrices. Understanding the dispersion and interaction of these nanofillers is crucial for modifying properties in technological applications. Homogeneously dispersed fillers boost physiochemical and biological properties, like mechanical strength and biocompatibility. These functional materials are employed in tissue engineering and other healthcare applications, maintaining their characteristics even in challenging conditions. In the biomedical field, these fillers show promise in developing stimuli-responsive systems, drug delivery, gene vectors, and biological imaging.