Due to imaging sensors' constraints, it is difficult to acquire a medical image that subsequently incorporates functional metabolic data and anatomical tissue characteristics. An important tool to aid in diagnostic procedures and intra-operative management is multimodal medical image fusion, an efficient method to combine the supplemental information gathered from numerous modalities. This research proposes a unique fusion approach for multimodal medical images that makes use of mean filter and maximum symmetric surround saliency detection. First, the images to be fused are decomposed into base layer and a series of detail layers via mean filter. While the guided filtering based fusion rule is used to merge the detail layers, for the fusion of base layer, a linear summation is employed. The fused base and detail images are subsequently combined to construct the final fused image. The proposed medical image fusion method performed more effectively than existing cutting-edge approaches in the context of both visual appearance and quantitative assessment, according to careful evaluation on a widely used database. The proposed method overcomes the challenge of cutting-edge image fusion methods in maintaining substantial edges and energy information on multi-modal medical images.

Peptic ulcer is a common disease with a high clinical incidence and frequent recurrences. The well-characterized galactomannan-type polysaccharide, extracted from Cassia grandis seeds, can accelerate the stages of wound healing and improve the remodeling of the extracellular matrix of injured tissues; this way, the gastroprotective potential of the galactomannan was proposed to be evaluated in the treatment of rat peptic ulcers induced by ethanol. Galactomannan was extracted by ethanol precipitation and prepared at 0.1, 1.0, and 10 mg/kg concentrations. Male Wistar rats were randomly divided into groups (n = 5) and orally treated with saline (negative control, NC), galactomannan at 0.1 mg/Kg (G0.1), galactomannan at 1.0 mg/Kg (G1), galactomannan at 10 mg/Kg (G10), and lansoprazole 30 mg/Kg (positive control, CP). Ethanol (1 mL/100 g of body mass) was administered 1 h after the treatments and, after another hour, the animals were euthanized. The stomachs were removed, fixed between Petri dishes, and photographed to calculate the percentage of the injured regions by computerized software. Histological analysis and the quantification of lipid peroxidation and reduced glutathione (GSH) were also performed. G1 and G10 reduced the injured area (P < 0.001) by 40 and 36%, respectively, concerning NC. It was observed the preservation of the gastric mucosa in all of the animals treated with galactomannan, in addition to reduced (P < 0.001) lipid peroxidation and GSH levels higher (P < 0.05) than NC. The galactomannan extracted from C. grandis seeds showed gastroprotective activity at 1.0 and 10 mg/kg by reducing the area of ulceration and oxidative stress.