Guest Editor(s)
School of Information and Communication Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Special Issue Information
Micro-nano probes and biosensors represent a rapidly evolving frontier in biomedical engineering, offering unprecedented capabilities for advanced diagnostics and precision therapeutics. By integrating functional nanomaterials, biorecognition elements, and microfabrication technologies, these devices enable highly sensitive, selective, and real-time detection of a wide range of biological targets, including nucleic acids, proteins, metabolites, and pathogenic microorganisms. Their miniaturized architectures facilitate minimally invasive monitoring and targeted intervention at the cellular and molecular levels, paving the way for early disease diagnosis, personalized medicine, and smart therapeutic delivery. In clinical diagnostics, micro-nano biosensors have demonstrated transformative potential for point-of-care testing, continuous health monitoring, and rapid pathogen detection. Meanwhile, in therapeutics, the integration of biosensing with responsive drug delivery systems is enabling closed-loop therapies with precise spatiotemporal control. Recent advancements in nanomaterials engineering, microfluidics, signal transduction mechanisms, and data analytics are further accelerating the development of next-generation biosensing platforms. This Special Issue aims to bring together cutting-edge research in the design, fabrication, characterization, and application of micro-nano probes and biosensors.
We welcome original research and review articles on topics including, but not limited to:
• Micro-nano probes for biosensing: Design and development of ultra-sensitive/ultra-ow background interference probes, multi-model probes, multi-functional probes, and motion-manipulated probes for high performance biosensing.
• Novel biosensing strategies: Design and development of innovative sensing mechanisms, including multi-modal signal transduction, nanomaterial-enabled enhancement, and ultra-sensitive detection methodologies.
• Wearable and implantable sensors: Engineering of flexible, biocompatible, and miniaturized devices for continuous health monitoring and real-time physiological data acquisition.
• Integrated diagnostic-therapeutic systems: Development of multifunctional platforms combining real-time biosensing with targeted, responsive therapeutic delivery for closed-loop healthcare applications.
• AI-enhanced biosensor data processing: Implementation of advanced machine learning algorithms and data analytics for intelligent signal interpretation, anomaly detection, and predictive diagnostics.
By providing a platform for the latest advancements, this Special Issue will contribute to the fundamental understanding and technological progress of Micro-nano probes and biosensors.
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