Engineering RNA Delivery Technologies for Vaccine and Therapeutic Development

  • Submission Deadline: 31 Jan 2026

Guest Editor(s)

Prof. Congcong Xu

International College of Pharmaceutical Innovation, Soochow University, Suzhou, Jiangsu, China.

Prof. Ang Lin

School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Special Issue Information

This Special Issue in BME Horizon focuses on cutting-edge advancements in RNA delivery technologies, emphasizing transformative engineering strategies to overcome critical bottlenecks in vaccine and therapeutic development. RNA-based therapies hold immense promise, but their clinical translation remains hindered by challenges such as delivery efficiency, stability, immune evasion, tissue-specific targeting, and scalable manufacturing. This Issue invites contributions addressing innovative approaches to RNA carrier design—including lipid nanoparticles, polymer-based systems, viral vectors, and hybrid platforms—alongside novel chemical modifications, biomaterial optimizations, and computational modeling tools.

We particularly welcome interdisciplinary research bridging academia and industry, showcasing solutions with high translational potential.

Topics of interest include but are not limited to: 
• Organ-selective delivery of RNA
• Intracellular release mechanisms
• In vivo pharmacology
• Manufacturing process
• Regulatory considerations

Submissions highlighting clinical applications in infectious diseases, cancer immunotherapy, or genetic disorders are encouraged. By uniting global experts, this Issue aims to accelerate the development of robust, clinically viable RNA delivery systems that redefine biomedical innovation.

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