Science Exploration Press is pleased to announce the official launch of Proteostasis, a new peer-reviewed, gold open-access journal dedicated to advancing fundamental and translational research in protein homeostasis.

Protein homeostasis - or proteostasis - is essential for cellular and organismal health. It encompasses the integrated processes that govern protein synthesis, folding, maturation, trafficking, quality control, stress responses, and degradation. When these systems are disrupted, proteostasis failure can contribute to ageing and a broad range of diseases, including neurodegenerative disorders, cancer, metabolic disease, and inflammatory conditions.

Proteostasis provides an interdisciplinary platform for research that reveals how cells maintain molecular balance in changing environments, and how this balance can be restored or therapeutically targeted in disease.

We are honoured to welcome Professor Claudio Hetz as the Editor-in-Chief of Proteostasis. Professor Hetz is a leading researcher in protein folding stress, the unfolded protein response, and neurodegenerative diseases. He holds appointments at the Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, and the Buck Institute for Research on Aging in the United States. His work has made influential contributions to understanding the molecular mechanisms of ER stress and proteostasis in physiology and disease.

Professor Claudio Hetz

Under Professor Hetz's leadership, Proteostasis is supported by an international Editorial Board with expertise spanning protein folding, ER stress and UPR signaling, ubiquitin–proteasome pathways, autophagy, protein aggregation, ageing, cancer, metabolism, and neurodegeneration.

The journal welcomes Research Articles, Reviews, Systematic Reviews, Short Communications, Perspectives, and other article types covering the broad spectrum of proteostasis research, including:
Protein synthesis, folding, maturation, and trafficking
• Protein quality control and stress responses
• Ubiquitin–proteasome, autophagy, and lysosomal degradation pathways
• Protein misfolding, aggregation, and neurodegenerative diseases
• Biomarkers, advanced therapies, and small-molecule interventions
• Systems biology, omics approaches, new methods, and disease models
• Translational and clinical studies targeting proteostasis

As a quarterly gold open-access journal, Proteostasis ensures that published research is freely available to the global community. Articles are published under the CC BY 4.0 license, with authors retaining copyright, and are archived in Portico for long-term preservation. The journal does not charge Article Processing Charges (APCs) for submissions published before January 1, 2031.

We warmly invite researchers, clinicians, and scientists across the proteostasis community to contribute to Proteostasis and join us in building a vibrant international forum for discovery, discussion, and collaboration.

Learn more about Proteostasis: https://www.sciexplor.com/proteostasis